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科学家开发新技术 可以大规模生产生物降解微型机器人_我的网站

一 |     为了创造一种每分钟可以生产100多个可在体内分解的微机器人技术，大邱庆北科技学院（DGIST）机器人和机电工程系的Hongsoo Choi教授团队与韩国天主教大学首尔圣玛丽医院的Sung-Won Kim教授团队以及苏黎世联邦理工学院的Bradley J. Nelson教授团队合作。
以微创靶向精准治疗为目标，构建微型机器人的方法有很多。    Nation's modernization drive delivers inclusive benefits to other countries     In 2008, as the global financial crisis unfolded, Greece suffered some of the worst fallout. Piraeus Port, the largest seaport in the country, reported a loss of 13 million euros ($15 million), with outdated facilities, scarce vessel calls and frequent dockworker strikes dragging its operations into a deep crisis.        During this challenging period, when investors worldwide deemed Greece too risky, a Chinese company stepped forward. China COSCO Shipping secured a concession to operate two of Piraeus' container terminals. Eight years later, in 2016, COSCO acquired a majority stake in the port, officially taking over its management and operations.    By bringing in expertise, investment and machinery, the Chinese company successfully breathed new life into the port. Far from replacing local staff, it created thousands of jobs for Greeks. Today, after years of restructuring, Piraeus stands as one of the busiest ports in the Mediterranean.    Charalampos Aravantinos-Simonetos, a youth coordinator for international and European affairs in Greece's Syriza party, shared the story of solidarity and cooperation with a roomful of young political leaders from China and Central and Eastern European countries, or CEECs, in June during a forum held in Wuhan, Hubei province.    The Chinese approach, he said, stands in stark contrast to those countries that invest solely for their own benefit and show little concern for local communities. The project has helped strengthen bilateral ties and allowed both sides to benefit through economic cooperation, he added.    According to Piraeus' financial report, the port achieved record total revenue of 251 million euros in 2025, up 8.6 percent year-on-year.    The turnaround of Piraeus Port, far from an isolated story, is a microcosm of the cooperation synergy between China and Central and Eastern European countries under the China-CEEC Cooperation mechanism.    Launched in 2012, the mechanism is a trans-regional platform jointly initiated by both sides. Over the past 14 years, the parties have remained committed to the principles of equality, mutual benefit in cooperation, openness and inclusiveness against the backdrop of a fluid international landscape.    Today, it has grown into a full-fledged mechanism, with deepening cooperation and a series of outcomes delivering tangible benefits to various parties.    In Croatia, the Chinese-built Peljesac Bridge has reduced a three-hour detour to just a few minutes' drive. In Serbia, Chinese investment has revived a century-old steel plant from the brink of closure. In Skopje, the capital of North Macedonia, thousands of citizens commute every day on buses manufactured by Chinese company Yutong Bus.    Such projects have "greatly facilitated local travel and daily commutes, injected robust momentum into industrialization and urbanization, and constantly improved people's well-being", said Xiang Yuanzheng, an official with the Chinese Commerce Ministry's European Department.    Over the years, bilateral cooperation has moved beyond traditional fields such as mining and logistics into emerging sectors. Contemporary Amperex Technology and other Chinese battery makers have set up plants in Hungary, Slovakia and Poland, while Slovenian pharmaceutical company Krka Group has launched a joint venture with Ningbo Menovo Pharmaceutical in East China's Zhejiang province.    From 2012 to 2025, trade between China and the CEECs registered an average annual growth rate of over 8 percent, hitting a record high of 1.09 trillion yuan ($161.5 billion) in 2025. In the first half of this year, two-way trade volume reached 580.1 billion yuan, up 11 percent year-on-year, according to the General Administration of Customs.    For Petre Danci, a Romanian who studied at Capital University of Economics and Business in Beijing from 2011 to 2018, China's modernization drive delivers inclusive benefits to other countries, an approach he believes is underpinned by the country's deep-rooted commitment to openness, mutual benefit and shared progress.    Citing the four great inventions of ancient China — papermaking, printing, the compass and gunpowder — Danci said that none of these transformative innovations changed the world by staying inside China. "They changed the world because they moved, because they were shared, because people who never met the inventors gained access to the tools and used them to build something entirely new," he said.    During his years in China, Danci witnessed the country's modernization drive firsthand, epitomized by the rise of China's "new four great inventions" — high-speed rail, mobile payments, bike-sharing and e-commerce.    "China does not just invent things; it deploys them at scale, and the results speak for themselves," he said, adding that such technological advancement "is changing the lives of hundreds of millions of people in real time" not just in China, but also in other countries.    Drawing a parallel between past and present, Danci noted that just as ancient inventions connected the world through trade routes and shared knowledge, nations today are connected through people-to-people and technological exchanges across borders. "The cooperation between China and CEECs is a clear example of this connection," he said.    Across the Eurasian region, this deepening connection has taken tangible shape. Irena Lukajic Korica, an adviser to the Office of the Serb Member of the Presidency of Bosnia and Herzegovina, said her country is among the top recipients of Chinese-backed infrastructure and energy projects in Central and Eastern Europe, with the total value of these projects reaching nearly 2 billion euros.    Noting that China's remarkable pace of development — transforming itself into one of the world's leading economies within just a few decades — has won widespread recognition in Bosnia and Herzegovina, Korica said young people in her country embrace the joint pursuit of modernization of China and the CEECs as opportunities for mutual learning, cooperation and shared development.    "They believe deeper cooperation can unlock new prospects in areas such as digital transformation, green energy, scientific research, tourism, cultural exchange and entrepreneurship," she said.    "Young people across my country are interested in the educational opportunities that China offers," she added, noting that for them, "China is no longer a distant country, but a place where they can study, gain experience and better understand a different culture and development model."    Michal Bartek, a member of the Slovak Parliament and deputy governor of Slovakia's Trencin region, said that every time he visits China, he brings back something unique.    "China is really inspirational for us," he said. "You have achieved remarkable progress in national development, and I hope to introduce valuable experience to my region."                    。其中最受欢迎的是被称为双光子聚合法的超精细3D打印工艺，它通过两个激光器相交引发合成树脂的聚合。

二 | 这种技术有能力创建具有纳米级精度的结构。

三 | 缺点是创建一个微型机器人需要大量的时间，因为体素，即通过3D打印实现的像素，必须连续固化。此外，在双光子聚合过程中，机器人中的磁性纳米粒子可能会阻碍光路。当利用高浓度的磁性纳米粒子时，过程结果可能不均匀。为了解决目前微机器人生产技术的限制，DGIST教授Hongsoo Choi的研究团队创造了一种方法，通过将磁性纳米颗粒和可生物降解的甲基丙烯酸明胶的混合物流到微流控芯片上，以每分钟100个的高速度制造微机器人，该混合物可以通过光固化。与现有的双光子聚合方法相比，这可以使制造微型机器人的速度提高1万倍以上。然后，用这种技术生产的微型机器人与从人的鼻子中收集的人类鼻甲骨干细胞进行培养，以诱导干细胞粘附到微型机器人的表面。通过这一过程，制造了一个干细胞携带的微型机器人，包括内部的磁性纳米颗粒和附着在外表面的干细胞。当机器人内部的磁性纳米粒子对外部磁场作出反应时，机器人就会移动，并能移动到所需的位置。
在现有的干细胞疗法中，选择性的细胞输送是困难的。然而，携带干细胞的微型机器人可以通过实时控制电磁场控制系统产生的磁场而移动到所需的位置。研究小组进行了一项实验，检查携带干细胞的微型机器人是否能通过一个迷宫状的微通道到达目标点，并因此证实机器人可以移动到所需的位置。此外，通过将携带微型机器人的干细胞与一种降解酶进行孵化，评估了微型机器人的可降解性。孵化6小时后，微机器人完全解体，机器人内部的磁性纳米粒子被磁场控制系统产生的磁场收集。干细胞在微型机器人被解体的地方增殖。随后，干细胞被诱导分化成神经细胞，以确认正常分化；干细胞在大约21天后被分化成神经细胞。该实验验证了使用微型机器人将干细胞运送到所需位置是可能的，而且运送的干细胞可以通过表现出增殖和分化来作为一种有针对性的精确治疗剂。

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Published on:01:26:16